I. Abstract
II. Background: Types of Stem Cells
A. Human Embryonic Stem Cells (hESCs)
1. Early, 5-7 days (totipotent)
2. Gonadal Ridge, 6 months (multipotent)
B. Fetal Stem Cells (pluripotent)
C. Umbilical Cord Stem Cells (multipotent)
1. Cord Blood
2. Cord Matrix / Whartons Jelly
D. Dental Stem Cells (multipotent)
E. Adult Stem Cells (multipotent)
1. Hematopoietic Stem Cells
2. Mesenchymal Stem Cells
3. Neuronal Stem Cells
F. Cancer Stem Cells (multipotent)
G. Animal Stem Cells (multipotent)
H. Novel Stem Cell Types
1. Induced Pluripotent Stem (iPS) Cells
2. Neural Rosette Cells (R-NSCs)
3. Very Small Embryonic Like (VSEL) Stem Cells
III. Stem Cell Research Applications
A. Regenerative medicine (Cell-Based Therapies)
1. Diabetes and Kidney Disease Research
2. Cardiovascular Disease Research
3. Neurological Diseases
4. Autoimmune diseases
5. Hematopoietic Disease and Transplantation Research
6. Orthopedic Diseases
7. Cancer Research
B. Drug Screening, Discovery, and Development
1. Assays to Aid Early Stage Discovery
2. Improved Prediction of Human Responses
3. Drug Development with Humanized Mouse Models
4. Genetically-Engineered Stem Cell Lines for Screening
C. Birth Defect Research
IV. Market Segments, By End-User
A. Basic Research: Understanding how micro-environmental cues modulate andguide stem cell differentiation and organization
B. Applied Research
1. Autologous and Allogeneic Cell Therapy
2. Toxicology Screening for Drug Discovery and Development
V. Product Areas
A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection
D. Protein Purification and Analysis Tools
1. Protein Purification
2. Stem Cell Protein Analysis
3. Quantitative Proteomics
E. DNA/RNA Based Characterization
1. Tools for DNA and RNA Based Characterization
2. Stem Cell HLA Typing
3. Stem Cell Nucleic Acid Extraction and Purification, and Associated PCR/RT-PCRReagents
F. Isolation / Characterization Services
1. Stem Cell HLA Typing Services
2. Stem Cell Custom Services
3. Stem Cell Custom Antibodies
G. Stem Cell Culture Media and Reagents
H. Growth Factors and Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Cell Tracking
K. Expansion / Differentiation Services
L. Stem Cell Lines
VI. Market Assessment (Data-Driven Analysis)
A. Breakdown of Stem Cell Research Activity, by Cell Type
B. Breakdown of Stem Cell Research Activity, by Species
C. Sources of Funding
1. Federal
2. State
3. Private
D. Patent Analysis
E. Publication Rate Analysis
1. Overview of Stem Cell Publication Rates
2. Comparative Analysis of Stem Cell Publication Rates
F. Geographical Analysis: Domestic vs. International Status
VII. Market Trends (Primary Market Survey)
A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Breakdown of Respondents by Industry Affiliation
3. Breakdown of Respondents by Duration of Stem Cell Activity
C. Breakdown of Stem Cell Research Activity, by Cell Type
D. Dominant Stem Cell Markers
E. Market Penetration of Stem Cell Markers
1. Mesenchymal Stem Cell (MSC) Markers
2. Human Embryonic Stem Cell (hESC) Markers
3. Neural Stem Cells (NSC) Markers
4. Hematopoietic Stem Cells (HSC) Markers
F. Most Frequently Utilized Providers of Stem Cell Antibodies
VIII. Key Market Competitors
A. Invitrogen
1. Products
a. Isolation and Characterization Stem Cell Products
b. Expansion and Differentiation Stem Cell Products
2. Collaborations
a. Invitrogen and Cellartis ABb. Invitrogen and Novocell
B. BD Biosciences
1. Products
a. Isolation
b. Culturing
c. Analysis
2. Collaborations: BD Biosciences and Stem Cell Technologies
C. Comparison of Invitrogen and BD Biosciences Stem Cell Publication Rates
IX. Market Size
A. Definition of Stem Cell Research Products
B. Experimental Approach
C. Stem Cell Research Products, Market Size (in Millions)
D. Stem Cell Antibodies, Market Size (in Millions)
E. Stem Cell Therapies, Market Size (in Billions)
X. Market Forecasts
A. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery
B. Short-term (3-5yrs): Therapeutics Involving Cord Blood and Adult Stem Cells
C. Long-Terms (10yrs): Therapeutics involving hESCs
XI. Competitive Landscape
A. Market Opportunities
B. Market Risks
XII. Communications Strategies for Accessing the Marketplace
A. Top Research Institutions Performing Stem Cell Research
1. University of Wisconsin
2. Johns Hopkins
3. NIH
4. California Institute for Regenerative Medicine
B. Events of Interest
C. Leads
1. NIH Funding Announcements by Institute
2. NIH Stem Cell Interest Group (SCIG)
3. NIH Stem Cell Program Staff: List of email and phone contacts
APPENDIX (Supplemental Documents)
Table I. NIH-Supported Stem Cell Training Courses
Table II. Additional Stem Cell Training Courses
Table III. NIH Funding Announcement by Institute
Table IV. Contact Information for the Stem Cell Interest Group (SCIG)
Steering Committee
Table V. Contact Information for the Stem Cell Interest Group (SCIG)Members
Table VI. NIH Contacts for Heads of Stem Cell Institutes and Centers